Timea Nagy Simon




Timea Nagy Simon


Ph.D. Physics, "Babes-Bolyai" University, Cluj-Napoca, Romania 2013. Title: Photosensitizer-Loaded Polymer-Gold Nanoparticle Hybrids for Enhancement of Photodynamic Therapy and Multimodal Cell Imaging

M. Sc. Biophysics and Medical Physics, "Babes-Bolyai" University, Cluj-Napoca, Romania 2010. Title: Pluronic micro-emulsions of hydrophobic chromophores for bio-imaging applications and photodynamic therapy

B. Sc. Medical Physics, "Babes-Bolyai" University, Cluj-Napoca, Romania 2008


Research Interests:

Synthesis of noble metal nanoparticles and conjugation with funcional molecules. Biomedical applications of nanoparticle: imaging, detection and cancer therapy (Photodynamic and photothermal therapy, drug delivery).



Chemical synthesis and functionalization of gold nanoparticles; Spectroscopic (UV-Vis, fluorescence, Raman, SERS) and dynamic light scattering (DLS) measurements; Fluorescence and dark field scattering microscopy; Cell cultures.

Latest publications:

  1. T. Nagy Simon, A. Tatar, A. M. Craciun, A. Vulpoi, M. A. Jurj, A. Florea, C. Tomuleasa, I. Berindan-Neagoe, S. Astilean, S. Boca, Antibody Conjugated, Raman Tagged Hollow Gold–Silver Nanospheres for Specific Targeting and Multimodal Dark-Field/SERS/Two Photon-FLIM Imaging of CD19(+) B Lymphoblasts, ACS Appl. Mater. Interfaces 9 (2017) 21155-68. (doi)
  2. K. Magyari, T. Nagy Simon, A. Vulpoi, R.A. Popescu, E. Licarete, R. Stefan, K. Hernádi, I. Papuc, L. Baia, Novel bioactive glass-AuNP composites for biomedical applications, Mater. Sci. Eng., C 76 (2017) 752-759. (doi)
  3. M. Potara, T. Nagy Simon, A. M. Craciun, S. Suarasan, E. Licarete, F. Imre Lucaci, and S. Astilean, Carboplatin-Loaded, Raman-Encoded, Chitosan-Coated Silver Nanotriangles as Multimodal Traceable Nanotherapeutic Delivery Systems and pH Reporters inside Human Ovarian Cancer Cells, ACS Appl. Mater. Interfaces 9 (2017) 32565–32576. (doi)
  4. S. Boca, C. Lucan, I. Frinc, B. Petrushev, T. Simon, C. Berce et al., Gold Nanoparticles Conjugated with Rituximab for the Treatment of Chronic Lymphocytic Leukemia, FARMACIA 64 (2016) 688-698. (doi)
  5. A. Tatar, T. Nagy Simon, C. Tomuleasa, S. Boca, S. Astilean, Nanomedicine approaches in acute lymphoblastic leukemia, J. Controlled Release 238 (2016) 123-138. (doi)
  6. B. Petrushev, S. Boca, T. Simon, C. Berce, I. Frinc, D. Dima, S. Selicean, G.-A. Gafencu, A. Tanase, M. Zdrenghea, A. Florea, S. Suarasan, L. Dima, R. Stanciu, A. Jurj, A. Buzoianu, A. Cucuianu, S. Astilean, A. Irimie, C. Tomuleasa, I. Berindan-Neagoe, Gold nanoparticles enhance the effect of tyrosin kinase inhibitors in acute myeloid leukemia therapy, Int. J. Nanomedicine 11 (2016) 641-660. (doi)
  7. S. Suarasan, T. Simon, S. Boca, C. Tomuleasa, S. Astilean, Gelatin coated gold nanoparticles as carriers of FLT3 inhibitors for acute myeloid leukemia treatment, Chem Biol Drug Des 87 (2016) 927-935. (doi)
  8. T. Simon, M. Potara, A. M. Gabudean, E. Licarete, M. Banciu, S. Astilean, Designing Theranostic Agents Based on Pluronic Stabilized Gold Nanoaggregates Loaded with Methylene Blue for Multimodal Cell Imaging and Enhanced Photodynamic Therapy, ACS Appl. Mater. Interfaces 7 (2015) 16191-16201. (doi)
  9. T. Simon, C. Tomuleasa, A. Bojan, I. Berindan-Neagoe, S. Boca and S. Astilean, Design of FLT3 Inhibitor - Gold Nanoparticle Conjugates as Potential Therapeutic Agents for the Treatment of Acute Myeloid Leukemia, Nanoscale Res. Lett. 10 (2015) 466. (doi)
  10. M. Potara, M. Bawaskar, T. Simon, S. Gaikwad, E. Licarete, A. Ingle, M. Banciu, A. Vulpoi, S. Astilean, M. Rai, Biosynthesized silver nanoparticles performing as biogenic SERS-nanotags for investigation of C26 colon carcinoma cells, Colloids Surf. B 133 (2015) 296-303. (doi)
  11. S. Boca-Farcau, M. Potara, T. Simon, A. Juhem, P. Baldeck and S. Astilean, Folic Acid-Conjugated, SERS-Labeled Silver Nanotriangles for Multimodal Detection and Targeted Photothermal Treatment on Human Ovarian Cancer Cells, Mol. Pharm. 11 (2014) 391–399. (doi)
  12. C. Tira, D.S. Tira, T. SImon, S. Astilean, Finite-Difference Time-Domain (FDTD) design of gold nanoparticle chains with specific surface plasmon resonance, J. Mol. Struct. 1072 (2014) 137-–143. (doi)
  13. B. Marta, E. Jakab, M. Potara, T. Simon, F. Imre-Lucaci,L. Barbu-Tudoran, O. Popescu, S. Astilean, Pluronic-coated silver nanoprisms: Synthesis, characterization andtheir antibacterial activity, Colloids Surf. A 441 (2014) 77-83. (doi)
  14. M. Iliut, A. M. Gabudean, C. Leordean, T. Simon, C. M. Teodorescu, S. Astilean, Riboflavin enhanced fluorescence of highly reduced graphene oxide, Chem. Phys. Lett. 586 (2013) 127–131. (doi)
  15. T. Simon, S. Boca, A. M. Gabudean, P. Baldeck, S. Astilean, LED-activated methylene blue-loaded Pluronic-nanogold hybrids for in vitro photodynamic therapy, J Biophotonics 6 (2013) 950-959. (doi)

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