Sanda Boca

sanda.boca[at]phys.ubbcluj.ro

Position:

Researcher

Sanda Boca

Education:

PhD, "Babes-Bolyai" University, Cluj-Napoca, Romania, 2011. (PhD Thesis title: “Desingning new plasmonic nanoparticles and photoactive molecules for bioimaging and cancer therapy”)

M. Sc. Biophysics and Medical Physics, "Babes-Bolyai" University, Cluj-Napoca, Romania 2007 (Master Dissertation title: “Organometallic nanoparticles for imaging and phototherapy of cancer cells by one and two-photon absorption”)

B. Sc. Medical Physics, "Babes-Bolyai" University, Cluj-Napoca, Romania 2006 (Dissertation title: "Preparation, characterization and functionalization of gold nanosubstrates for plasmonic biosensors)

 

Research Interests:

- colloidal nanoparticle synthesis and (bio)functionalization; - optical (micro)spectroscopy; - biomedical application of noble-metal nanoparticles (cellular imaging, photo-thermal therapy of cancer cells)

 

Skills:

-chemical synthesis of colloidal nanoparticles;

-nanoparticle (bio)functionalization;

-surface enhanced Raman scattering (SERS) spectroscopy;

-optical microscopy;

-cell biology/cell culture;

Latest publications:

  1. T. Nagy Simon, A. Tatar, A. M. Craciun, A. Vulpoi, M. A. Jurj, A. Florea, C. Tomuleasa, I. Berindan-Neagoe, S. Astilean, S. Boca, Antibody Conjugated, Raman Tagged Hollow Gold–Silver Nanospheres for Specific Targeting and Multimodal Dark-Field/SERS/Two Photon-FLIM Imaging of CD19(+) B Lymphoblasts, ACS Appl. Mater. Interfaces 9 (2017) 21155-68. (doi)
  2. C. Berce, C. Lucan, B. Petrushev, S. Boca, M. Miclean, O. Sarpataki, S. Astilean, A. Buzoianu, C. Tomuleasa, A. Bojan, In vivo assessment of bone marrow toxicity by gold nanoparticle-based bioconjugates in Crl:CD1(ICR) mice, Int J Nanomedicine 11 (2016) 4261–4273. (doi)
  3. S. Boca, C. Farcau, M. Baia, S. Astilean, Metanephrine neuroendocrine tumor marker detection by SERS using Au nanoparticle/Au film sandwich architecture, Biomed. Microdevices 18 (2016) 12:1-10. (doi)
  4. S. Boca, C. Lucan, I. Frinc, B. Petrushev, T. Simon, C. Berce et al., Gold Nanoparticles Conjugated with Rituximab for the Treatment of Chronic Lymphocytic Leukemia, FARMACIA 64 (2016) 688-698. (doi)
  5. S. Suarasan, T. Simon, S. Boca, C. Tomuleasa, S. Astilean, Gelatin coated gold nanoparticles as carriers of FLT3 inhibitors for acute myeloid leukemia treatment, Chem Biol Drug Des 87 (2016) 927-935. (doi)
  6. B. Petrushev, S. Boca, T. Simon, C. Berce, I. Frinc, D. Dima, S. Selicean, G.-A. Gafencu, A. Tanase, M. Zdrenghea, A. Florea, S. Suarasan, L. Dima, R. Stanciu, A. Jurj, A. Buzoianu, A. Cucuianu, S. Astilean, A. Irimie, C. Tomuleasa, I. Berindan-Neagoe, Gold nanoparticles enhance the effect of tyrosin kinase inhibitors in acute myeloid leukemia therapy, Int. J. Nanomedicine 11 (2016) 641-660. (doi)
  7. A. Tatar, T. Nagy Simon, C. Tomuleasa, S. Boca, S. Astilean, Nanomedicine approaches in acute lymphoblastic leukemia, J. Controlled Release 238 (2016) 123-138. (doi)
  8. N.Djaker, S. Sultana, D.Issaad, S. Boca, H. Moustaoui, J.Spadavecchia, A. Medjahed, M. Bouafia, S. Astilean, M. Lamy de la Chapelle, Spherical and Flower-Shaped Gold Nanoparticles Characterization by Scattering Correlation Spectroscopy, J. Phys. Chem. C 120 (2016) 11700–11708. (doi)
  9. S. Boca, Mihaela Aldea, Ioan Alexandru Florian, Gabriel Kacso, Lucian Craciun, Sanda Boca, Olga Soritau, Ioan Stefan Florian, Nanoparticles for Targeting Intratumoral Hypoxia: Exploiting a Potential Weakness of Glioblastoma, Pharmaceutical Research 33 (2016) 2059–2077. (doi)
  10. C. Farcau, R. A. L. Vallee, S. Boca, S. Astilean, Polarized SERS on linear arrays of silver half-shells: SERS re-radiation modulated by local density of optical states, J. Opt. 17 (2015) 114007. (doi)
  11. T. Simon, C. Tomuleasa, A. Bojan, I. Berindan-Neagoe, S. Boca and S. Astilean, Design of FLT3 Inhibitor - Gold Nanoparticle Conjugates as Potential Therapeutic Agents for the Treatment of Acute Myeloid Leukemia, Nanoscale Res. Lett. 10 (2015) 466. (doi)
  12. S. Boca, C. Leordean, S. Astilean, C. Farcau, Chemiresistive/SERS dual sensor based on densely packed gold nanoparticles, Beilstein J. Nanotechnol. 6 (2015) 2498-2503. (doi)
  13. S. Sultana, S. Boca, N. Djaker, M. Salerno, N. Charnaux, S. Astilean, H. Hlawaty and M. L. de la Chapelle, Comparative toxicity evaluation of flower-shaped and spherical gold nanoparticles on human endothelial cells, Nanotechnology 26 (2015) 055101. (doi)
  14. C. Leordean, M. Potara, S. Boca-Farcau, A. Vulpoi, S. Astilean and C. Farcau, Multiscale electromagnetic SERS enhancement on self-assembled micropatterned gold nanoparticle films, J. Raman Spectrosc. 45 (2014) 627. (doi)
  15. S. Boca, Monica Potara, Timea Simon, Aurelie Juhem, Patrice Baldeck, Simion Astilean, Folic Acid-Conjugated, SERS-Labeled Silver Nanotriangles for Multimodal Detection and Targeted Photothermal Treatment on Human Ovarian Cancer Cells, Mol. Pharmaceutics 11 (2014) 391-9. (doi)
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