Ana-Maria Craciun (Gabudean)

Position:

CS III (from march 2014)

Education:

PhD, "Babes-Bolyai" University, Cluj-Napoca, Romania 2012, Title:"Multifunctional plasmonic nanoparticles for optical imaging and detection methods "

M. Sc. Biophysics and Medical Physics, "Babes-Bolyai" University, Cluj-Napoca, Romania 2010. Dissertation title: New nanoparticles for biophotonic applications: fluorescent gold nanoshells for bioimaging and photoactive pluronic nanobeads for phototherapy

B. Sc. Medical Physics, "Babes-Bolyai" University, Cluj-Napoca, Romania 2008

Research Interests:

>> implement a label-free efficient optical biosensing method based on probing the photoluminescence of gold nanoparticles by fluorescence correlation spectroscopy (FCS) >> synthesis and characterization of multifunctional nanoparticles for biomedical application, such as detection and bioimaging >> implementation of new analysis and spectroscopic imaging methods based on time-resolved and steady-state confocal fluorescence microscopy and spectroscopy (MicoTime 200 system from PicoQuant coupled with a Ti:Sa femtosecond laser)

Skills:

Chemical synthesis of multifunctional gold nanoparticles;

Time-resolved fluorescence microscopy and spectroscopy;

Nonlinear optical measurements (two-photon excited fluorescence, SHG);

Fluorescence correlation spectroscopy (FCS)

Spectroscopic (UV-Vis, fluorescence, Raman, SERS) and dynamic light scattering (DLS) measurements ;

Optical microscopy (bright and dark field, fluorescence);

Finite-Difference Time-Domain (FDTD) numerical simulations;

Latest publications:

1. A. Campu, F. Lerouge, D. Chateau, F. Chaput, P. Baldeck, S. Parola, D. Maniu, A. M. Craciun, A. Vulpoi, S. Astilean, M. Focsan, Gold NanoBipyramids Performing as Highly Sensitive Dual-Modal Optical Immunosensors, Anal. Chem. 90 (2018) 8567-8575. (doi)
2. M. Potara, M. Focsan, A. M. Craciun, I. Botiz, S. Astilean, Polymer-coated plasmonic nanoparticles for environmental remediation: Synthesis, functionalization, and properties chapter in New Polymer Nanocomposites for Environmental Remediation, Elsevier - (2018) 361–387. (doi)
3. T. Nagy Simon, M. Potara, A. M. Craciun, E. Licarete, S. Astilean, IR780-dye loaded gold nanoparticles as new near infrared activatable nanotheranostic agents for simultaneous photodynamic and photothermal therapy and intracellular tracking by surface enhanced resonant Raman scattering imaging, J. Colloid Interface Sci. 517 (2018) 239-250. (doi)
4. A. M. Craciun, M. Focsan, K. Magyari, A. Vulpoi, Z. Pap, Surface Plasmon Resonance or Biocompatibility—Key Properties for Determining the Applicability of Noble Metal Nanoparticles, Materials 10 (2017) 836. (doi)
5. A. M. Craciun, M. Focsan, L. Gaina, S. Astilean, Enhanced one- and two-photon excited fluorescence of cationic (phenothiazinyl)vinyl-pyridinium chromophore attached to polyelectrolyte-coated gold nanorods, Dyes Pigm. 136 (2017) 24-30. (doi)
6. T. Nagy Simon, A. Tatar, A. M. Craciun, A. Vulpoi, M. A. Jurj, A. Florea, C. Tomuleasa, I. Berindan-Neagoe, S. Astilean, S. Boca, Antibody Conjugated, Raman Tagged Hollow Gold–Silver Nanospheres for Specific Targeting and Multimodal Dark-Field/SERS/Two Photon-FLIM Imaging of CD19(+) B Lymphoblasts, ACS Appl. Mater. Interfaces 9 (2017) 21155-68. (doi)
7. M. Potara, T. Nagy Simon, A. M. Craciun, S. Suarasan, E. Licarete, F. Imre Lucaci, and S. Astilean, Carboplatin-Loaded, Raman-Encoded, Chitosan-Coated Silver Nanotriangles as Multimodal Traceable Nanotherapeutic Delivery Systems and pH Reporters inside Human Ovarian Cancer Cells, ACS Appl. Mater. Interfaces 9 (2017) 32565–32576. (doi)
8. A. M. Craciun, A. Diac, M. Focsan, C. Socaci, K. Magyari, D. Maniu, I. Mihalache, L. M. Veca, S. Astilean, A. Terec, Surface passivation of carbon nanoparticles with p-phenylenediamine towards photoluminescent carbon dots, RSC Adv. 6 (2016) 56944-56951. (doi)
9. M. Focsan (Iosin), A. M. Craciun, S. Astilean, P. L. Baldeck, Two-photon fabrication of three-dimensional silver microstructures in microfluidic channels for volumetric surface-enhanced Raman scattering detection, Opt. Mater. Express 6 (2016) 1587-1593. (doi)
10. T. Simon, M. Potara, A. M. Gabudean, E. Licarete, M. Banciu, S. Astilean, Designing Theranostic Agents Based on Pluronic Stabilized Gold Nanoaggregates Loaded with Methylene Blue for Multimodal Cell Imaging and Enhanced Photodynamic Therapy, ACS Appl. Mater. Interfaces 7 (2015) 16191-16201. (doi)
11. A. Diac, M. Focsan, C. Socaci. A. M. Gabudean, C. Farcau, D. Maniu, E. Vasile, A. Terec, L. M. Veca, S. Astilean, Covalent conjugation of carbon dots with Rhodamine B and assessment of their photophysical properties, RSC Adv. 5 (2015) 77662-77669. (doi)
12. B. Brem, E. Gal, L. Gaina, C. Cristea, A. M. Gabudean, S. Astilean, L. Silaghi-Dumitrescu, Metallo complexes of meso-phenothiazinylporphyrins: synthesis, linear and nonlinear optical properties, Dyes Pigm. 123 (2015) 386-395. (doi)
13. P. Moutet, N. M. Sangeetha, L. Ressier, N. Vilar-Vidal, M. Comesana-Hermo, S. Ravaine, R. A. L. Vallee, A. M. Gabudean, S. Astilean, C. Farcau, Surface-enhanced spectroscopy on plasmonic oligomers assembled by AFM nanoxerography, Nanoscale 7 (2015) 2009-2022. (doi)
14. A. Gabudean, R. Groza, D. Maniu, S. Astilean, teady-state and time-resolved fluorescence studies on the conjugation of Rose Bengal to gold nanorods, J. Mol. Struct. 1073 (2014) 97-–101. (doi)
15. T. Simon, S. Boca, A. M. Gabudean, P. Baldeck, S. Astilean, LED-activated methylene blue-loaded Pluronic-nanogold hybrids for in vitro photodynamic therapy, J Biophotonics 6 (2013) 950-959. (doi)